Nothing in the menus is staying ticked or selected

[MochaMoa]

I've been playing on the PJ64 for the past week, on a daily basis (in my spare time) but only when I booted it up today was there an issue. I couldnt select cheats, change settings, change options, or anything. When I'd try to change them, they'd simply clear themselves as soon as I clicked Apply or exited the window. I've tried shutting it down and opening it back up again, but the problem persist. How can I fix this?

[Freedbot]

check task manager to see if there's another project64 process hung in the background (or just restart your computer). Did you move project64 to a write protected folder so it can't save it's own settings? Some programs have this issue if you move them to Program Files. You can also right click the program/shortcut and run as administrator and see if that helps.